Current Approaches for Diagnosis of Influenza Virus Infections in Humans
Identifieur interne : 000870 ( Main/Exploration ); précédent : 000869; suivant : 000871Current Approaches for Diagnosis of Influenza Virus Infections in Humans
Auteurs : Sai Vikram Vemula ; Jiangqin Zhao ; Jikun Liu ; Xue Wang ; Santanu Biswas ; Indira HewlettSource :
- Viruses [ 1999-4915 ] ; 2016.
Abstract
Despite significant advancement in vaccine and virus research, influenza continues to be a major public health concern. Each year in the United States of America, influenza viruses are responsible for seasonal epidemics resulting in over 200,000 hospitalizations and 30,000–50,000 deaths. Accurate and early diagnosis of influenza viral infections are critical for rapid initiation of antiviral therapy to reduce influenza related morbidity and mortality both during seasonal epidemics and pandemics. Several different approaches are currently available for diagnosis of influenza infections in humans. These include viral isolation in cell culture, immunofluorescence assays, nucleic acid amplification tests, immunochromatography-based rapid diagnostic tests,
Url:
DOI: 10.3390/v8040096
PubMed: 27077877
PubMed Central: 4848591
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Current Approaches for Diagnosis of Influenza Virus Infections in Humans</title><author><name sortKey="Vemula, Sai Vikram" sort="Vemula, Sai Vikram" uniqKey="Vemula S" first="Sai Vikram" last="Vemula">Sai Vikram Vemula</name></author><author><name sortKey="Zhao, Jiangqin" sort="Zhao, Jiangqin" uniqKey="Zhao J" first="Jiangqin" last="Zhao">Jiangqin Zhao</name></author><author><name sortKey="Liu, Jikun" sort="Liu, Jikun" uniqKey="Liu J" first="Jikun" last="Liu">Jikun Liu</name></author><author><name sortKey="Wang, Xue" sort="Wang, Xue" uniqKey="Wang X" first="Xue" last="Wang">Xue Wang</name></author><author><name sortKey="Biswas, Santanu" sort="Biswas, Santanu" uniqKey="Biswas S" first="Santanu" last="Biswas">Santanu Biswas</name></author><author><name sortKey="Hewlett, Indira" sort="Hewlett, Indira" uniqKey="Hewlett I" first="Indira" last="Hewlett">Indira Hewlett</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27077877</idno><idno type="pmc">4848591</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848591</idno><idno type="RBID">PMC:4848591</idno><idno type="doi">10.3390/v8040096</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000056</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000056</idno><idno type="wicri:Area/Pmc/Curation">000056</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000056</idno><idno type="wicri:Area/Pmc/Checkpoint">000280</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000280</idno><idno type="wicri:Area/Ncbi/Merge">000543</idno><idno type="wicri:Area/Ncbi/Curation">000543</idno><idno type="wicri:Area/Ncbi/Checkpoint">000543</idno><idno type="wicri:Area/Main/Merge">000872</idno><idno type="wicri:Area/Main/Curation">000870</idno><idno type="wicri:Area/Main/Exploration">000870</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Current Approaches for Diagnosis of Influenza Virus Infections in Humans</title><author><name sortKey="Vemula, Sai Vikram" sort="Vemula, Sai Vikram" uniqKey="Vemula S" first="Sai Vikram" last="Vemula">Sai Vikram Vemula</name></author><author><name sortKey="Zhao, Jiangqin" sort="Zhao, Jiangqin" uniqKey="Zhao J" first="Jiangqin" last="Zhao">Jiangqin Zhao</name></author><author><name sortKey="Liu, Jikun" sort="Liu, Jikun" uniqKey="Liu J" first="Jikun" last="Liu">Jikun Liu</name></author><author><name sortKey="Wang, Xue" sort="Wang, Xue" uniqKey="Wang X" first="Xue" last="Wang">Xue Wang</name></author><author><name sortKey="Biswas, Santanu" sort="Biswas, Santanu" uniqKey="Biswas S" first="Santanu" last="Biswas">Santanu Biswas</name></author><author><name sortKey="Hewlett, Indira" sort="Hewlett, Indira" uniqKey="Hewlett I" first="Indira" last="Hewlett">Indira Hewlett</name></author></analytic><series><title level="j">Viruses</title><idno type="eISSN">1999-4915</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Despite significant advancement in vaccine and virus research, influenza continues to be a major public health concern. Each year in the United States of America, influenza viruses are responsible for seasonal epidemics resulting in over 200,000 hospitalizations and 30,000–50,000 deaths. Accurate and early diagnosis of influenza viral infections are critical for rapid initiation of antiviral therapy to reduce influenza related morbidity and mortality both during seasonal epidemics and pandemics. Several different approaches are currently available for diagnosis of influenza infections in humans. These include viral isolation in cell culture, immunofluorescence assays, nucleic acid amplification tests, immunochromatography-based rapid diagnostic tests, <italic>etc.</italic> Newer diagnostic approaches are being developed to overcome the limitations associated with some of the conventional detection methods. 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